An enormous amount of observations on Cosmic Microwave Background radiation has been collected in the last decade, and much more data are expected in the near future from planned or operating satellite missions. These datasets are a goldmine of information for Cosmology and Theoretical Physics; their efficient exploitation posits several intriguing challenges from the statistical point of view. In this paper we review a number of open problems in CMB data analysis and we present applications to observations from the WMAP mission.

Published in at http://dx.doi.org/10.1214/08-AOAS190 the Annals of Applied Statistics (http://www.imstat.org/aoas/) by the Institute of Mathematical Statistics (http://www.imstat.org)