Introduction and Overview Tocotrienols: A Review, A.G. Schauss Tocotrienols in Vitamin E: Hype or Science?, N.E. Levin and D.L. Clouatre Sources Tocotrienols: Distribution and Sources Cereals-Role in Human Health, H. Zielinski Tocotrienols in Plants: Sources and Importance, L. Harinantenaina Vitamin E: Natural vs. Synthetic, A. Kosowski and D.L. Clouatre Chemistry of Tocotrienols Angiogenesis Inhibition, K. Nakagawa, A. Shibata, P. Sookwong and T. Miyazawa Chemistry of Tocotrienols, S.P. Ghosh, M. Hauer-Jensen, and K.S. Kumar Mechanisms of Action Antioxidant Activity of Tocotrienols in Cells and Serum, R. Simone and P. Palozza Antioxidant Action of Tocotrienols and Tocopherols in Solution and Membranes: Chemical and Physical Effects, Y. Yoshida and E. Niki Antiproliferative and Apoptotic Effects of Tocotrienols on Normal and Neoplastic Mammary Epithelial Cells, P.W. Sylvester DNA Polymerase Inhibition, Y. Mizushina, H. Yoshida, and T. Miyazawa Tocotrienols in Altering the Expression of Adhesion Molecules, Y. Naito and T. Yoshikawa Uptake, Distribution and Protective Action of Tocotrienols in Cultured Cells, N. Noguchi, Y. Saito and E. Niki Cancer Prevention and Treatment Anticancer Effects of Tocotrienols and Tocopherols Irrespective of Anti-Oxidative Properties, T. Yano and N. Virgona Role of the MevalonatePathway in Tocotrienol-Mediated Tumor Suppression, H. Mo and C.E. Elson Telomerase Inhibition, T. Eitsuka, K. Nakagawa and T. Miyazawa Heart Disease Tocopherol and Tocotrienols: Role in Heart Disease Care and Prevention, V. Juturu Tocotrienols and the Regulation of Cholesterol Biosynthesis, J. Cao, W. Qi and B.-L. Song Tocotrienols in Cardiometabolic Diseases, B. Tan and A.M. Mueller Tocotrienols in Hyperlipidemic Conditions, J. Iqba1 and M. Minhajuddin Vitamin E Isomers, Tocotrienols, in Cardioprotection, S. Das, M. Das and D.K. Das Metabolism and Absorption Absorption and Disposition of Tocotrienols, K.-H. Yuen, B.-H. Ng and J.-W. Wong The Metabolism of Tocopherols and Tocotrienols and Novel Functions of Their Metabolites, Q. Jiang Tocotrienols Activate the Steroid and Xenobiotic Receptor SXR to Modulate Small Molecule Metabolism, K.R. Johnson, T. Hsu, and B. Blumberg Health Promotion Tocotrienols in the Potential Treatment of Infectious Disease, A. M. Mueller, B. Tan and E. S. Stuart Tocotrienols as Natural Neuroprotective Vitamins, C.K. Sen, S. Khanna and S. Roy Gamma-Tocotrienol: Potential as a Countermeasure against Radiological Threat, K.S. Kumar, S.P. Ghosh and M. Hauer-Jensen Index