The use of ephedrine for medicinal purposes dates back over 5000 years, when native Chinese physicians Ma Huang in the late 1800s, but was considered too toxic for clinical use; it was rediscovered by Chen & Schmidt (1930), who demonstrated its sympatho mimetic action and introduced it into Western medicine, where it was found to be a big improvement on adrenaline in the treatment of asthma. That the structure of ephedrine is very similar to that of amphetamine is not a coincidence, since Alles (1933) synthesised the latter as a synthetic substitute for ephedrine.