Interleukin-4 receptor alpha gene variants and allergic disease
Copyright policy )Interleukin-4 receptor alpha gene variants and allergic disease
The interleukin-4 (IL-4) signalling cascade has been identified as a pathway potentially important in the development of asthma. Genetic variants within this signalling pathway might contribute to the risk of developing asthma in a given individual. A number of polymorphisms have been described within the IL-4 receptor alpha (IL-4Ralpha) gene. In addition polymorphism occurs in the promoter for the IL-4 gene itself. This commentary accompanies a paper by C Ober et al describing the contribution of IL-4Ralpha polymorphism to susceptibility to asthma and atopy in the Hutterite population and other outbred populations collected during the collaborative studies on the genetics of asthma (CSGA) programme.
- University of Nottingham United Kingdom
Pulmonary and Respiratory Medicine, Polymorphism, Genetic, RC705-779, Genetic Variation, interleukin-13, Receptors, Interleukin-4, Diseases of the respiratory system, Commentary, Hypersensitivity, Humans, Protein Isoforms, genetics, interleukin-4, asthma atopy
Pulmonary and Respiratory Medicine, Polymorphism, Genetic, RC705-779, Genetic Variation, interleukin-13, Receptors, Interleukin-4, Diseases of the respiratory system, Commentary, Hypersensitivity, Humans, Protein Isoforms, genetics, interleukin-4, asthma atopy
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