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Aspirin Resistance in Patients Undergoing Hemodialysis and Effect of Hemodialysis on Aspirin Resistance

descriptionPublicationkeyboard_double_arrow_right Article 22 May 2013 English Publisher:SAGE PublicationsJournal:Clinical and Applied Thrombosis/Hemostasis, volume 21, pages 82-86 (issn: 1076-0296, eissn: 1938-2723,

Authors: Nevzat Uslu; Savas Ozturk; Derya Yavuz; Mehmet Gül; Nilgun Isiksacan; Hale Unal Aksu; Sami Uzun; +3 Authors

doi: 10.1177/1076029613489597

pmid: 23698727

Aspirin Resistance in Patients Undergoing Hemodialysis and Effect of Hemodialysis on Aspirin Resistance

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Abstract

The aim of this study was to evaluate the prevalence of aspirin resistance (AR) in patients undergoing hemodialysis (HD) and to assess the effect of HD on the results of the Multiplate test. A total of 54 patients undergoing HD were included in this study. Blood samples were taken just before and after the HD session. To determine AR, we used Multiplate test. Platelet aggregation values of the study population were 363.01 ± 225.69 aggregation unit (AU) × minutes before and 375.33 ± 254.05 AU × minutes after the HD ( P = .597). There was strong correlation between the values before and after HD ( R = .755, P < .0001). The AR status was changed in 9 (16.6%) patients after HD. Agreement of AR status before and after HD was substantial (κ coefficient = .667, P < .0001). The prevalence of AR in patients undergoing HD seems higher than in most of the studied populations, and this study has shown that the AR statuses of a significant number of patients undergoing HD change after an HD session.

Keywords

Adult, Male, Aspirin, Platelet Aggregation, Platelet Function Tests, Drug Resistance, Middle Aged, Renal Dialysis, Humans, Kidney Failure, Chronic, Female, Platelet Aggregation Inhibitors, Aged

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