Building on the Psychology of Working Framework, the current study explored the extent to which work volition functioned as a moderator in the relation between positive affect, core self-evaluations, perceived organizational support (POS), and work self-efficacy to job satisfaction. In a diverse sample of 206 employed adults, work volition was found to be a significant moderator in the relations of self-efficacy and POS to job satisfaction. Specifically, as work volition increased, the relation of self-efficacy to job satisfaction increased, whereas the relation of POS to job satisfaction decreased. Results of this study lend initial support to the proposition that the strength and direction of established predictors of job satisfaction depend, in part, on an individual’s level of work volition. Implications for research and practice are discussed.