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Journal of Vision
Article . 2011 . Peer-reviewed
Data sources: Crossref
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Journal of Vision
Article
License: CC BY NC ND
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Protection against deprivation amblyopia depends on relative not absolute daily binocular exposure

Authors: Mitchell, Donald E; Sengpiel, Frank; Hamilton, David C; Schwarzkopf, D Samuel; Kennie, Jan;

Protection against deprivation amblyopia depends on relative not absolute daily binocular exposure

Abstract

Short daily periods of binocular exposure (BE) can offset longer single daily episodes of monocular exposure (ME) to prevent the development of deprivation amblyopia. To determine whether the outcome depended upon an absolute daily amount of BE or its proportion of the daily visual exposure, daily mixed visual input of 3 different durations (3.5, 7, or 12 h) was imposed on 3 cohorts of kittens. Measurements of the visual acuity of the deprived eye at the end of mixed daily visual input revealed that the acuity of the deprived eye developed to normal values so long as the proportion of the total exposure that was binocular was 30% or more. By contrast, the development of functional ocular dominance domains in V1 revealed by optical imaging suggests that normal domains emerge with a fixed amount of daily binocular exposure. The latter result is consistent with the effects of any daily period of ME, or BE, or both, effectively saturating with a small dose so that the effects of ME of any length can be offset by a short period of BE. The different result for vision may reflect neural events at higher and/or multiple levels in the visual pathway.

Country
New Zealand
Keywords

Vision, 150, 610, Eye, Amblyopia, Clinical Research, Ocular, 3212 Ophthalmology and optometry, Animals, Visual Pathways, Dominance, Eye Disease And Disorders Of Vision, 11 Medical and Health Sciences, Visual Cortex, Vision, Binocular, Animal, Neurosciences, Binocular, Brain Disorders, 17 Psychology and Cognitive Sciences, Dominance, Ocular, Disease Models, Animal, 1701 Psychology, Disease Models, Cats, Sensory Deprivation, Photic Stimulation

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
18
Average
Average
Top 10%
gold