The incidence of bovine lymphosarcoma was studied in 79,492 male adult Indian cattle of 7 different breeds and crossbreeds from one abattoir in Bombay. One of 23,066 Malvi animals, a bullock, was detected with multicentric LS with symmetrically enlarged lymph nodes and spleen. Examination of blood, lymph nodes and spleen confirmed the leukotic condition of the animal. The incidence of bovine LS in India and Western countries is compared, and the interrelationship between leukemia in different species of domestic animals and man is discussed. The need for further epidemiological studies of leukemia in domestic pets and food producing animals in India is suggested.