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Markedly Elevated Carbamazepine-10,11-epoxide/Carbamazepine Ratio in a Fatal Carbamazepine Ingestion

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 01 Jan 2015 English Publisher:WileyJournal:Case Reports in Medicine, volume 2,015, pages 1-4 (issn: 1687-9627, eissn: 1687-9635,

Authors: Jason L. Russell; Daniel D Baker; Henry A. Spiller;

doi: 10.1155/2015/369707

pmid: 26550016

pmc: PMC4621337

Markedly Elevated Carbamazepine-10,11-epoxide/Carbamazepine Ratio in a Fatal Carbamazepine Ingestion

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Abstract

Carbamazepine is a widely used anticonvulsant. Its metabolite, carbamazepine-10,11-epoxide, has been found to display similar anticonvulsant and neurotoxic properties. While the ratio of parent to metabolite concentration varies significantly, at therapeutic doses the epoxide concentration is generally about 20% of the parent. We report a case of fatal carbamazepine overdose in which the epoxide metabolite concentration was found to be 450% higher than the parent compound, suggesting a potential role for metabolite quantification in severe toxicity.

Related Organizations

Nationwide Children's Hospital
United States
The Ohio State University Wexner Medical Center
United States

Keywords

R, Medicine, Case Report

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	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
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