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Parkinson's Disease
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Nonmotor Symptoms in a Malaysian Parkinson’s Disease Population

الأعراض غير الحركية لدى السكان الماليزيين المصابين بمرض باركنسون
Authors: Shahrul Azmin; Abdul Manaf Khairul Anuar; Hui Jan Tan; Wan Yahya Nafisah; Azman Ali Raymond; Zulhabri Othman; Shamsul Azhar Shah; +1 Authors

Nonmotor Symptoms in a Malaysian Parkinson’s Disease Population

Abstract

Background. The nonmotor symptoms are important determinants of health and quality of life in Parkinson’s disease but are not well recognized and addressed in clinical practice. This study was conducted to determine the prevalence of nonmotor symptoms and their impact on quality of life in patients with Parkinson’s disease.Methods. This was a cross-sectional study among patients with idiopathic Parkinson’s disease. Exclusion criteria were a Mini Mental State Examination score of <21/30. Prevalence of nonmotor symptoms was determined using the NMSQuest. The severity of nonmotor symptoms and the quality of life were assessed using validated disease-specific questionnaires (PDQ-39 and NMSS).Results. A total of 113 patients consisting of 60 males and 53 females were recruited. The median duration of illness was 5.0 (2.0–8.0) years. The prevalence rate of nonmotor symptoms in our cohort was 97.3%. The most common reported nonmotor symptom in our cohort was gastrointestinal (76.1%). We found that the severity of the nonmotor symptoms was associated with poorer quality of life scores (rs: 0.727,P<0.001).Conclusions. Nonmotor symptoms were highly prevalent in our patients with Parkinson’s disease and adversely affected the quality of life of our patients. In contrast to western studies, the most common nonmotor symptom is gastrointestinal. The possibility of an Asian diet playing a role in this observation requires further study.

Keywords

Epidemiology, Parkinson's disease, Population, Nursing, FOS: Health sciences, Non-motor Symptoms, Epidemiology and Management of Restless Legs Syndrome, Health Sciences, FOS: Mathematics, Disease, RC346-429, Internal medicine, Quality of life (healthcare), Deep Brain Stimulation for Neurological Disorders, Cohort, Algorithm, Environmental health, Neurology, Medicine, Neurology. Diseases of the nervous system, Pathophysiology of Parkinson's Disease, Mathematics, Research Article

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
21
Top 10%
Top 10%
Top 10%
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