This study shows climate projections of air temperature and precipitation over South America (SA) from the Regional Climate Model version 3 (RegCM3) nested in ECHAM5 and HadCM3 global models. The projections consider the A1B scenario from Intergovernmental Panel on Climate Change (IPCC) and three time-slices: present (1960–1990), near- (2010–2040), and far-future (2070–2100) climates. In the future, RegCM3 projections indicate general warming throughout all SA and seasons, which is more pronounced in the far-future period. In this late period the RegCM3 projections indicate that the negative trend of precipitation over northern SA is also higher. In addition, a precipitation increase over southeastern SA is projected, mainly during summer and spring. The lifecycle of the South American monsoon (SAM) was also investigated in the present and future climates. In the near-future, the projections show a slight delay (one pentad) of the beginning of the rainy season, resulting in a small reduction of the SAM length. In the far-future, there is no agreement between projections related to the SAM features.