By introducing auxiliary functions, we investigate the oscillation of a class of second‐order sub‐half‐linear neutral impulsive differential equations of the form [r(t)ϕβ(z′(t))] ′ + p(t)ϕα(x(σ(t))) = 0, t ≠ θk, where β > α > 0, z(t) = x(t) + λ(t)x(τ(t)). Several oscillation criteria for the above equation are established in both the case 0 ≤ λ(t) ≤ 1 and the case −1 < −μ ≤ λ(t) ≤ 0, which generalize and complement some existing results in the literature. Two examples are also given to illustrate the effect of impulses on the oscillatory behavior of solutions to the equation.