Cell Adhesion by Integrins
Copyright policy )Cell Adhesion by Integrins
Integrins are heterodimeric cell surface receptors ensuring the mechanical connection between cells and the extracellular matrix. In addition to the anchorage of cells to the extracellular matrix, these receptors have critical functions in intracellular signaling, but are also taking center stage in many physiological and pathological conditions. In this review, we provide some historical, structural, and physiological notes so that the diverse functions of these receptors can be appreciated and put into the context of the emerging field of mechanobiology. We propose that the exciting journey of the exploration of these receptors will continue for at least another new generation of researchers.
- Tampere University Finland
- University of Geneva Switzerland
- Tampere University Finland
- Tampere University Finland
- Tampere University Finland
Models, Molecular, Integrins, Mechanotransduction, integrin, Protein Conformation, 612, Mechanotransduction, Cellular, Structure-Activity Relationship, fibronectin, Models, Cell Adhesion, Animals, Humans, Adaptor Proteins, Signal Transducing, Cell Proliferation, Signal Transducing/metabolism, talin, Cell Membrane/metabolism, Cell Membrane, Sisätaudit - Internal medicine, Intracellular Signaling Peptides and Proteins, Adaptor Proteins, Molecular, cell adhesion, YAP-Signaling Proteins, Extracellular Matrix/metabolism, Phosphoproteins, Extracellular Matrix, Phosphoproteins/metabolism, Intracellular Signaling Peptides and Proteins/metabolism, Transcriptional Coactivator with PDZ-Binding Motif Proteins, Integrins/chemistry/metabolism, Trans-Activators, mechanosensing, Cellular, Transcription Factors
Models, Molecular, Integrins, Mechanotransduction, integrin, Protein Conformation, 612, Mechanotransduction, Cellular, Structure-Activity Relationship, fibronectin, Models, Cell Adhesion, Animals, Humans, Adaptor Proteins, Signal Transducing, Cell Proliferation, Signal Transducing/metabolism, talin, Cell Membrane/metabolism, Cell Membrane, Sisätaudit - Internal medicine, Intracellular Signaling Peptides and Proteins, Adaptor Proteins, Molecular, cell adhesion, YAP-Signaling Proteins, Extracellular Matrix/metabolism, Phosphoproteins, Extracellular Matrix, Phosphoproteins/metabolism, Intracellular Signaling Peptides and Proteins/metabolism, Transcriptional Coactivator with PDZ-Binding Motif Proteins, Integrins/chemistry/metabolism, Trans-Activators, mechanosensing, Cellular, Transcription Factors
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