NOD-Like Receptors: Guardians of Intestinal Mucosal Barriers

descriptionPublicationkeyboard_double_arrow_right Article 01 May 2015 English Publisher:American Physiological SocietyJournal:Physiology, volume 30, pages 241-250 (issn: 1548-9213, eissn: 1548-9221,

Copyright policy )Funded by:NSERC | unidentified, CIHR | unidentified

Authors: Anne-Kathrin, Claes; Jun Yu, Zhou; Dana J, Philpott;

doi: 10.1152/physiol.00025.2014

pmid: 25933824

NOD-Like Receptors: Guardians of Intestinal Mucosal Barriers

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Abstract

The NOD-like receptors (NLRs) are cytosolic pattern-recognition receptors, which are critically involved in mucosal immune defense. The association of the NLR, NOD2, with inflammatory bowel disease first pointed to the NLRs potential function as guardians of the intestinal barrier. Since then, several studies have emphasized the importance of NLRs in maintaining gut homeostasis and intestinal infections, and in shaping the microbiota. In this review, we will highlight the function of NLRs in intestinal inflammation.

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Keywords

Bacteria, Inflammasomes, Bacterial Infections, Permeability, Gastroenteritis, Bacterial Translocation, Host-Pathogen Interactions, Nod Signaling Adaptor Proteins, Animals, Humans, Intestinal Mucosa, Immunity, Mucosal, Signal Transduction

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