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Exercise-induced mitral regurgitation and right ventricle to pulmonary circulation uncoupling across the heart failure phenotypes

descriptionPublicationkeyboard_double_arrow_right Article 01 Feb 2021 Italy, United Kingdom Publisher:American Physiological SocietyJournal:American Journal of Physiology-Heart and Circulatory Physiology, volume 320, pages H642-H653 (issn: 0363-6135, eissn: 1522-1539,

Authors: Bandera, Francesco; Barletta, Marta; Fontana, Marianna; Boveri, Sara; Ghizzardi, Greta; Alfonzetti, Eleonora; Ambrogi, Federico; +1 Authors

doi: 10.1152/ajpheart.00507.2020

pmid: 33306448

handle: 2434/1007628

Exercise-induced mitral regurgitation and right ventricle to pulmonary circulation uncoupling across the heart failure phenotypes

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Abstract

Ex-MR is a common mechanism across the spectrum of HF subtypes and combines with ventilatory inefficiency and RV-PC uncoupling. Interestingly, in HFpEF, Ex-MR emerged as unexpectedly prevalent and peculiarly associated with increased chronotropic response and peripheral O2 extraction as potential adaptive mechanisms to backward flow redistribution.

Countries

Italy, United Kingdom

Related Organizations

University of Milan
Italy
University College London
United Kingdom
University College of London
United Kingdom
Policlinico San Donato
Italy
University College London
United Kingdom

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Keywords

Male, CONTRACTILE FUNCTION, Pulmonary Circulation, right ventricle, Risk Factors, pulmonary hypertension, Prevalence, echocardiography, Humans, Prospective Studies, Exercise, Aged, Heart Failure, HFpEF; echocardiography; mitral regurgitation; pulmonary hypertension; right ventricle, Hemodynamics, Mitral Valve Insufficiency, Middle Aged, HFpEF, DYSFUNCTION, Echocardiography, Doppler, Color, CLINICAL PHENOTYPES, INSIGHTS, RESERVE, Phenotype, PRESERVED EJECTION FRACTION, Italy, Exercise Test, Ventricular Function, Right, Mitral Valve, Female, mitral regurgitation, ECHOCARDIOGRAPHY, Echocardiography, Stress

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Dataset from Bandera F, Barletta M, Fontana M, Boveri S, Ghizzardi G, Alfonzetti E, Ambrogi F, Guazzi M. Exercise-induced mitral regurgitation and right ventricle to pulmonary circulation uncoupling across the heart failure phenotypes. Am J Physiol Heart Circ Physiol. 2021 Feb 1;320(2):H642-H653. doi: 10.1152/ajpheart.00507.2020. Epub 2020 Dec 11. PMID: 33306448.
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