[Abstract] Python has become one of the most used and taught languages nowadays. Its expressiveness, cross-compatibility and ease of use have made it popular in areas as diverse as finance, bioinformatics or machine learning. However, Python programs are often significantly slower to execute than an equivalent native C implementation, especially for computation-intensive numerical kernels. This work presents PolyBench/Python, implementing the 30 kernels in PolyBench/C, one of the standard benchmark suites for polyhedral optimization, in Python. In addition to the benchmark kernels, a functional wrapper including mechanisms for performance measurement, testing, and execution configuration has been developed. The framework includes support for different ways to translate C-array codes into Python, offering insight into the tradeoffs of Python lists and NumPy arrays. The benchmark performance is thoroughly evaluated on different Python interpreters, and compared against its PolyBench/C counterpart to highlight the profitability (or lack thereof) of using Python for regular numerical codes. Ministerio de Ciencia e innovación; PID2019-104184RB-I00 Ministerio de Ciencia e innovación; AEI/10.13039/501100011033 U.S. National Science Foundation; CCF-1750399 Xunta de Galicia; ED431G 2019/01