The Endomycetaceae is redefined and expanded to include yeasts and fungi bearing ascocarps or ascophores but is restricted to genera producing either galeate ascospores or other characteristics indicating affinities to the central genus Ceratocystis. The genus Endomyces is emended and a neotype is selected for the type species, E. decipiens. Endomyces cortinarii sp. nov. and Phialoascus borealis gen. et sp. nov. are described. A key to the genera admitted to the Endomycetaceae and listed below is included: Ambrosiozyma, Amorphotheca, Ascoidea, Botryoascus, Cephaloascus, Ceratocystiopsis, Ceratocystis, Endomyees, Europhium, Hansenula, Hormoascus. Pachysolen, Ophiostoma. Phialoascus, and Stephanoascus. Zendera gen. nov. (Schizosaccharomycetaceae) and Galactomyces gen. nov. (Onygenaceae) are described. The following new combinations are made: Zendera tetrasperma (Macy et Miller) comb, nov., Z. ovetensis (Peláez et Ramirez) comb, nov., Galactomyces geotrichum (Butler et Petersen) comb. nov., G. reesü (van der Walt) comb, nov., and Magnusiomyces magnusü (Ludwig) comb. nov.