A syndrome is described in which parturient dairy cows showed clinical signs consistent with milk fever but failed to respond to conventional therapy. The affected cows were reluctant to walk, moved stiffy and in severe cases became recumbent. The condition was apparently precipitated by low vitaimin E and selenium intake, stress of pregnancy and in one outbreak erratic feeding. Skeletal and cardiac myodegeneration were observed grossly and histologically but an almost full term fetus from an affected cow showed no muscle lesions. A high incidence of retained placentae was also recorded.