Porcine circovirus type 2 (PCV-2) is the causative agent of a number of diseases and syndromes. Of these, postweaning multisystemic wasting syndrome (PMWS) is the most extensively studied, with the main lesions occurring in lymphoid tissues, although a number of other tissues can also be affected. Unthriftiness, respiratory distress and diarrhoea are frequently reported clinical signs. Neurological signs associated with lesions in the CNS are, however, uncommonly reported (Segales 2012). This report describes the occurrence of marked spinal cord injury in pigs associated with PCV-2 infection. The condition was observed in two finishing herds in southern Brazil composed of 400 pigs each. Clinical signs observed were staggering gait and paraparesis progressing to paralysis and permanent lateral decubitus. Death occurred within one day after recumbency due to acute bacterial pneumonia. Six 100-day-old to 120-day-old pigs displayed these clinical signs, four in one herd and two in the other. Postmortem examination was performed in two of these animals, one from each herd. The main necropsy findings were detected in the spinal cord, accompanied …