Let $\mathcal {A}$ be a unital $\ast$-algebra. For $A, B\in\mathcal{A}$, define by $[A, B]_{*}=AB-BA^{\ast}$ and $A\bullet B=AB+BA^{\ast}$ the new products of $A$ and $B$. In this paper, under some mild conditions on $\mathcal {A}$, it is shown that a map $Φ:\mathcal {A}\rightarrow \mathcal {A}$ satisfies $Φ([A\bullet B, C]_{*})=[Φ(A)\bullet B, C]_{*}+[A\bullet Φ(B), C]_{*}+[A\bullet B, Φ(C)]_{*}$ for all $A, B,C\in\mathcal {A}$ if and only if $Φ$ is an additive $*-$derivation. In particular, we apply the above result to prime $\ast$-algebras, von Neumann algebras with no central summands of type $I_1$, factor von Neumann algebras and standard operator algebras.