Bifidobacterium bifidum PRL2010 Modulates the Host Innate Immune Response

descriptionPublicationkeyboard_double_arrow_right Article 15 Jan 2014 Italy English Publisher:American Society for MicrobiologyJournal:Applied and Environmental Microbiology, volume 80, pages 730-740 (issn: 0099-2240, eissn: 1098-5336,

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Authors: F. Turroni; V. Taverniti; P. Ruas Madiedo; S. Duranti; S. Guglielmetti; G. A. Lugli; L. Gioiosa; +4 Authors

doi: 10.1128/aem.03313-13

pmid: 24242237

pmc: PMC3911076

handle: 10261/142562 , 2434/230201 , 10281/453739 , 11381/2761110

Bifidobacterium bifidum PRL2010 Modulates the Host Innate Immune Response

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Abstract

ABSTRACTHere, we describe data obtained from transcriptome profiling of human cell lines and intestinal cells of a murine model upon exposure and colonization, respectively, withBifidobacterium bifidumPRL2010. Significant changes were detected in the transcription of genes that are known to be involved in innate immunity. Furthermore, results from enzyme-linked immunosorbent assays (ELISAs) showed that exposure toB. bifidumPRL2010 causes enhanced production of interleukin 6 (IL-6) and IL-8 cytokines, presumably through NF-κB activation. The obtained global transcription profiles strongly suggest thatBifidobacterium bifidumPRL2010 modulates the innate immune response of the host.

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Keywords

570, Mice, Inbred BALB C, Gene Expression Profiling, Probiotics, Interleukin-8, NF-kappa B, 610, Enzyme-Linked Immunosorbent Assay, Heat-shock proteins; intestinal epithelial-cells; CACO-2 cells; gene-expression; in-vitro; lactobacillus-acidophilus; colorectal-carcinoma; ulcerative-colitis; dendritic cells; genome analysis, Immunity, Innate, Cell Line, Intestines, Mice, Animals, Cytokines, Humans, Female, Bifidobacterium, Caco-2 Cells, HT29 Cells

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