Artemisinins Inhibit Trypanosoma cruzi and Trypanosoma brucei rhodesiense In Vitro Growth
Copyright policy ) Mishina, Yuliya V.; Krishna, Sanjeev; Haynes, Richard K.; Meade, John C.;
Artemisinins Inhibit Trypanosoma cruzi and Trypanosoma brucei rhodesiense In Vitro Growth
ABSTRACT Artemisinin compounds inhibit in vitro growth of cultured Trypanosoma cruzi and Trypanosoma brucei rhodesiense at concentrations in the low micromolar range. Artemisinin also inhibits calcium-dependent ATPase activity in T. cruzi membranes, suggesting a mode of action via membrane pumps. Artemisinins merit further investigation as chemotherapeutic options for these pathogens.
China (People's Republic of)
- Hong Kong Polytechnic University China (People's Republic of)
- University of Mississippi Medical Center United States
- University of London United Kingdom
- St George's, University of London United Kingdom
- Hong Kong University of Science and Technology (香港科技大學) China (People's Republic of)
Trypanosoma brucei rhodesiense, Anti-Infective Agents, Parasitic Sensitivity Tests, Trypanosoma cruzi, Animals, Calcium-Transporting ATPases, Sesquiterpenes, Artemisinins
Trypanosoma brucei rhodesiense, Anti-Infective Agents, Parasitic Sensitivity Tests, Trypanosoma cruzi, Animals, Calcium-Transporting ATPases, Sesquiterpenes, Artemisinins
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selected citations
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These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
Citations provided by BIP!popularityPopularity provided by BIP!
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
Popularity provided by BIP! 111
Top 10%
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