High-fructose corn syrup enhances intestinal tumor growth in mice
Copyright policy )High-fructose corn syrup enhances intestinal tumor growth in mice
A sweetener's not-so-sweet effects Obesity increases an individual's risk of developing many types of cancer, including colorectal cancer. One of the factors driving the rise in obesity rates is thought to be the use of high-fructose corn syrup (HFCS) as a sweetener in soft drinks. Goncalves et al. found that ingestion of HFCS promotes the growth of intestinal cancer even in the absence of obesity in mouse tumor models. An enzyme in tumors (ketohexokinase) converts fructose to fructose-1-phosphate, which alters tumor cell metabolism and leads to enhanced cell growth. Whether a similar process occurs in humans remains to be seen. Science , this issue p. 1345
- Weill Cornell Medicine United States
- Chonnam National University Korea (Republic of)
- Baylor College of Medicine United States
- Tisch Cancer Institute United States
- University of Zurich Switzerland
1000 Multidisciplinary, Carcinogenesis, Adenomatous Polyposis Coli Protein, 610 Medicine & health, Mice, Mutant Strains, Diet, Tumor Burden, Mice, 10049 Institute of Pathology and Molecular Pathology, Intestinal Neoplasms, Animals, Neoplasm Grading, High Fructose Corn Syrup
1000 Multidisciplinary, Carcinogenesis, Adenomatous Polyposis Coli Protein, 610 Medicine & health, Mice, Mutant Strains, Diet, Tumor Burden, Mice, 10049 Institute of Pathology and Molecular Pathology, Intestinal Neoplasms, Animals, Neoplasm Grading, High Fructose Corn Syrup
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