This month and next month mark two important anniversaries in the field of particle physics—the 50th anniversary of the inauguration of Fermilab (the Fermi National Accelerator Laboratory, just outside of Chicago, Illinois) and the 5th anniversary of the Higgs boson discovery at CERN (the European Organization for Nuclear Research, in Geneva, Switzerland). These two institutions have been united in their commitment to elucidate the laws that govern the physical universe. Their main achievements (the discovery of bottom and top quarks at Fermilab, and of the W, Z, and Higgs bosons at CERN) reflect how Fermilab and CERN, with other laboratories around the world, have joined forces throughout these 50 years to prove right the “standard model”—the theory that describes the fundamental components of matter that we know of—or, to challenge it. Our quest to understand the makeup and behavior of the world, to answer fundamental questions about the past and future of our universe, and to explore the possible existence of an ultimate “theory of everything” should continue to be a worldwide effort.