Genome-wide inactivation of porcine endogenous retroviruses (PERVs)
Copyright policy )Genome-wide inactivation of porcine endogenous retroviruses (PERVs)
Virally cleansing the pig genome Transplants from pigs could be a solution to a shortage of human organs for transplantation. Unfortunately, porcine endogenous retroviruses (PERVs) are rife in pigs and can be transmitted to humans, risking disease. L. Yang et al. integrated CRISPR-Cas into the pig cell genome, where continuous induction of the Cas9 editing enzyme resulted in the mutation of every single PERV reverse transcriptase gene. This prevented replication of all copies of PERV, viral infection, and transmission to human cells. Science , this issue p. 1101
- Zhejiang Ocean University China (People's Republic of)
- Harvard University United States
- Massachusetts General Hospital United States
- Wyss Institute for Biologically Inspired Engineering United States
Base Sequence, Swine, Endogenous Retroviruses, Molecular Sequence Data, Transplantation, Heterologous, Gene Dosage, 610, Epithelial Cells, Kidney, Genes, pol, Cell Line, HEK293 Cells, 616, Gene Targeting, Animals, Humans, Virus Inactivation, CRISPR-Cas Systems, Retroviridae Infections
Base Sequence, Swine, Endogenous Retroviruses, Molecular Sequence Data, Transplantation, Heterologous, Gene Dosage, 610, Epithelial Cells, Kidney, Genes, pol, Cell Line, HEK293 Cells, 616, Gene Targeting, Animals, Humans, Virus Inactivation, CRISPR-Cas Systems, Retroviridae Infections
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