Chemotherapy-induced antitumor immunity requires formyl peptide receptor 1
Copyright policy )Chemotherapy-induced antitumor immunity requires formyl peptide receptor 1
How dying tumor cells get noticed Besides killing tumor cells directly, some chemotherapies, such as anthracyclines, also activate the immune system to kill tumors. Vacchelli et al. discovered that in mice, anthracycline-induced antitumor immunity requires immune cells to express the protein formyl peptide receptor 1 (FPR1). Dendritic cells (DCs) near tumors expressed especially high amounts of FPR1. DCs normally capture fragments of dying tumor cells and use them to activate nearby T cells to kill tumors, but DCs lacking FPR1 failed to do this effectively. Individuals with breast or colon cancer expressing a variant of FPR1 and treated with anthracyclines showed poor metastasis-free and overall survival. Thus, FPR1 may affect anti-tumor immunity in people, too. Science , this issue p. 972
- Istituto Superiore di Sanità Italy
- Université Bourgogne Franche-Comté France
- University of Paris-Saclay France
- Université Paris-Saclay France
- UNIVERSITE MARIE ET LOUIS PASTEUR France
T-Lymphocytes, Breast Neoplasms, microfluidic chip, chemotherapy, Polymorphism, Single Nucleotide, immune response, Mice, Cell Line, Tumor, Neoplasms, Leukocytes, Animals, Humans, Anthracyclines, dendritic cells; anthracycline chemotherapy; FPR1, Alleles, Annexin A1, Dendritic Cells, Receptors, Formyl Peptide, Immunity, Innate, Chemotherapy, Adjuvant, Female, Colorectal Neoplasms, FPR1 microfluidic
T-Lymphocytes, Breast Neoplasms, microfluidic chip, chemotherapy, Polymorphism, Single Nucleotide, immune response, Mice, Cell Line, Tumor, Neoplasms, Leukocytes, Animals, Humans, Anthracyclines, dendritic cells; anthracycline chemotherapy; FPR1, Alleles, Annexin A1, Dendritic Cells, Receptors, Formyl Peptide, Immunity, Innate, Chemotherapy, Adjuvant, Female, Colorectal Neoplasms, FPR1 microfluidic
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