Catalysis Propene is one of the highest-volume organic chemicals produced. Propene has mainly been made from naphtha, but changes in the global supply chain are creating shortages. Direct conversion from propane, a component of natural gas, via reaction with oxygen is an attractive alternative, but existing approaches produce a large fraction of unwanted CO and CO2. Grant et al. report that boron nitride, normally an unreactive material, has high selectivity to catalyze the production of propene (77%) and ethene (13%). Science , this issue p. [1570][1] [1]: /lookup/doi/10.1126/science.aaf7885