ESCRT Machinery Is Required for Plasma Membrane Repair
Copyright policy )ESCRT Machinery Is Required for Plasma Membrane Repair
ESCRT Your Wound Away The ESCRT (endosomal sorting complex required for transport) protein complex plays a role in budding into multivesicular bodies, in cytokinesis, and in HIV budding. Now, Jimenez et al. (p. 10.1126/science.1247136 , published online 30 January) propose a role for ESCRT proteins in wound repair at the plasma membrane. In vivo imaging, modeling, and electron microscopy were used to reveal how the ESCRTs participate in a rapid energy-independent, calcium-dependent, membrane-shedding process at the plasma membrane that reseals small wounds caused by toxins or laser treatment.
Endosomal Sorting Complexes Required for Transport, Calcium-Binding Proteins, Cell Membrane, Green Fluorescent Proteins, Cell Cycle Proteins, Digitonin, Saponins, Fluorescence, Bacterial Proteins, Gene Knockdown Techniques, Streptolysins, Humans, RNA, Small Interfering, HeLa Cells, Propidium
Endosomal Sorting Complexes Required for Transport, Calcium-Binding Proteins, Cell Membrane, Green Fluorescent Proteins, Cell Cycle Proteins, Digitonin, Saponins, Fluorescence, Bacterial Proteins, Gene Knockdown Techniques, Streptolysins, Humans, RNA, Small Interfering, HeLa Cells, Propidium
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