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Specific and Nonhepatotoxic Degradation of Nuclear Hepatitis B Virus cccDNA

descriptionPublicationkeyboard_double_arrow_right Article 14 Mar 2014 Switzerland, Belgium, France English Publisher:American Association for the Advancement of Science (AAAS)Journal:Science, volume 343, pages 1,221-1,228 (issn: 0036-8075, eissn: 1095-9203, Copyright policy )Funded by:EC | LIVERCANCERMECHANISM, DFG | Liver inflammation: infec...
Authors: Lucifora, Julie; Xia, Yuchen; Reisinger, Florian; Zhang, K.; Stadler, Daniela; Cheng, Xiaoming; Sprinzl, Martin; +17 Authors

doi: 10.1126/science.1243462

pmid: 24557838

pmc: PMC6309542

handle: 2268/178924

Specific and Nonhepatotoxic Degradation of Nuclear Hepatitis B Virus cccDNA

Abstract

Clearance of Chronic Virus The family of mRNA-editing enzymes, APOBEC, restricts hepatitis B virus (HBV) replication. Lucifora et al. (p. 1221 , published online 20 February; see the Perspective by Shlomai and Rice ) provide evidence that specific APOBECs mediate the anti-HBV effects of host cytokines, which in turn apparently induce nuclear deaminase activity without damaging host cells. Thus, there may be potential in these findings for developing a therapeutic route to curing chronic HBV infection.

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Switzerland, Belgium, France
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Keywords

Hepatitis B virus, Cytidine, Mice, SCID, Biochimie, biophysique & biologie moléculaire, Antiviral Agents, Cell Line, Minor Histocompatibility Antigens, Lymphotoxin beta Receptor, Cytidine Deaminase, Animals, Humans, [SDV.MP.VIR] Life Sciences [q-bio]/Microbiology and Parasitology/Virology, Cell Nucleus, Multidisciplinary, Antibodies, Monoclonal, Interferon-alpha, Proteins, Hepatitis B, Life sciences, [SDV.MHEP.HEG] Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology, Up-Regulation, Liver, [SDV.SP.PHARMA] Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology, DNA, Viral, [SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Sciences du vivant, Hepatocytes, DNA, Circular, Biochemistry, biophysics & molecular biology

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    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
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    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
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    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
822
Top 0.1%
Top 1%
Top 0.01%
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