Structural basis of the activation of the CC chemokine receptor 5 by a chemokine agonist
Copyright policy )Structural basis of the activation of the CC chemokine receptor 5 by a chemokine agonist
The structure of CCR5 in complex with [6P4]CCL5 and the G i protein reveals its activation mechanism.
- University of Basel Switzerland
- University of Geneva Switzerland
- Department of pathology and immunology Switzerland
- ETH Zurich Switzerland
- Swiss National Science Foundation Switzerland
Models, Molecular, Receptors, CCR5, Protein Conformation, Cryoelectron Microscopy, Receptors, CCR5 / chemistry, 616.07, Chemokine CCL5 / metabolism, Receptors, CCR5 / genetics, Molecular Dynamics Simulation, Chemokine CCL5 / chemistry, Chemokine CCL5/chemistry; Chemokine CCL5/metabolism; Cryoelectron Microscopy; Humans; Models, Molecular; Molecular Dynamics Simulation; Protein Conformation; Receptors, CCR5/agonists; Receptors, CCR5/chemistry; Receptors, CCR5/genetics; Receptors, CCR5/metabolism; Signal Transduction; Structure-Activity Relationship, Structure-Activity Relationship, Humans, Receptors, CCR5 / agonists, Receptors, CCR5 / metabolism, Chemokine CCL5, Research Articles, Signal Transduction
Models, Molecular, Receptors, CCR5, Protein Conformation, Cryoelectron Microscopy, Receptors, CCR5 / chemistry, 616.07, Chemokine CCL5 / metabolism, Receptors, CCR5 / genetics, Molecular Dynamics Simulation, Chemokine CCL5 / chemistry, Chemokine CCL5/chemistry; Chemokine CCL5/metabolism; Cryoelectron Microscopy; Humans; Models, Molecular; Molecular Dynamics Simulation; Protein Conformation; Receptors, CCR5/agonists; Receptors, CCR5/chemistry; Receptors, CCR5/genetics; Receptors, CCR5/metabolism; Signal Transduction; Structure-Activity Relationship, Structure-Activity Relationship, Humans, Receptors, CCR5 / agonists, Receptors, CCR5 / metabolism, Chemokine CCL5, Research Articles, Signal Transduction
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