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Discovery of a picomolar potency pharmacological corrector of the mutant CFTR chloride channel

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 21 Feb 2020 English Publisher:American Association for the Advancement of Science (AAAS)Journal:Science Advances, volume 6 (eissn: 2375-2548, Copyright policy )
Authors: Nicoletta Pedemonte; Fabio Bertozzi; Emanuela Caci; Federico Sorana; Paolo Di Fruscia; Valeria Tomati; Loretta Ferrera; +8 Authors

doi: 10.1126/sciadv.aay9669

pmid: 32128418

pmc: PMC7034990

handle: 11588/795517 , 11567/1021647

Discovery of a picomolar potency pharmacological corrector of the mutant CFTR chloride channel

Abstract

We identified a small molecule that, at picomolar concentrations, rescues mutant CFTR chloride channel from protein degradation.

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Keywords

Pharmaceutical Preparations, Cystic Fibrosis Transmembrane Conductance Regulator, Humans, Bronchi, Epithelial Cells, Mutant Proteins, Research Articles, Cell Line, High-Throughput Screening Assays

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    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 43
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    		 Top 10%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 Top 10%
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    		 Top 10%
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
43
Top 10%
Top 10%
Top 10%
Green
gold
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