In hot and humid regions, removal of moisture from the air represents a considerable portion of the air conditioning load. Conventionally, air conditioning systems have to lower the air temperature below its dew point to accomplish dehumidification. Desiccant air conditioners offer a solution to meet the humidity and temperature requirements of buildings via decoupling latent and sensible loads. In this work, the performance of a new desiccant material is investigated experimentally. This desiccant material can be regenerated using a low temperature heat source, as low as 45°C. It also has a unique S-shape isotherm. The effects of the process air stream’s temperature and humidity, the regeneration temperature, the ventilation mass flow rate, and the desiccant wheel’s rotational speed on the cycle performance are investigated. ARI-humid conditions are used as a baseline and the moisture mass balance is maintained within 5%. The results are presented in terms of the moisture removal rate and latent coefficient of performance (COPlat). The results show a desiccant wheel’s COPlat higher than unity when it is coupled with an enthalpy wheel.