van Vugt and colleagues found that sarcopenia is an independent risk factor for increased hospital costs for liver transplant candidates. (1) They report that diminished muscle mass measured on CT imaging as the skeletal muscle index (SMI, cm2 muscle area/m2 patient height) is strongly associated with increased hospitalizations and cost of care. The association was significant on multivariable modeling adjusted for potential confounders. This original observation using an anatomic muscle mass measurement is consistent with work showing that physical frailty measured by gait speed indicates similar risk for increased hospitalization and healthcare costs in such patients.(2) This article is protected by copyright. All rights reserved.