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Transplant Infectious Disease
Article . 2021 . Peer-reviewed
License: Wiley Online Library User Agreement
Data sources: Crossref
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International survey of human herpes virus 8 screening and management in solid organ transplantation

Authors: Mularoni, Alessandra; Mikulska, Malgorzata; Giannella, Maddalena; Adamoli, Lucia; Slavin, Monica; Van Delden, Christian; Garcia, Jose Maria Aguado; +2 Authors

International survey of human herpes virus 8 screening and management in solid organ transplantation

Abstract

AbstractBackgroundHHV‐8/Kaposi Sarcoma herpesvirus has been associated with a broad spectrum of diseases in solid organ transplant (SOT) recipients. Primary donor‐derived infection can be associated with severe and rapidly fatal non‐neoplastic disease, and diagnosis is made with high HHV‐8 DNAemia.MethodsWe carried out an international survey to investigate the current approach to HHV‐8 screening, and management in SOT since a protocol has not been established by international guidelines.ResultsA total of 51 transplant centers from 15 countries filled out the survey. HHV‐8‐associated diseases in SOT have been diagnosed during the previous 5 years in 67% of centers. Pretransplant serological screening is performed in 17 centers (33%), and posttransplant HHV‐8 nucleic acid testing (NAT) monitoring is performed in 21 centers (41%). Performing HHV‐8 NAT monitoring and serological screening were found associated with having diagnosed in the previous 5 years a non‐malignant HHV‐8‐associated disease.ConclusionsSerological pretransplant screening of donors and recipients and post‐transplant HHV‐8 NAT monitoring recommendations should be standardized. Even though serological assays are not optimal, they could contribute to increasing knowledge on epidemiology and management of HHV‐8‐associated diseases after SOT.

Countries
Italy, Italy, Australia, Switzerland
Keywords

human herpes virus 8; screening; solid organ transplant; survey, Herpesviridae Infections / diagnosis, Sarcoma, Kaposi / epidemiology, Organ Transplantation / adverse effects, 610, Herpesviridae Infections, Organ Transplantation, Transplant Recipients, Solid organ transplant, human herpes virus 8; screening; solid organ transplant; survey; Humans; Transplant Recipients; Herpesviridae Infections; Herpesvirus 8, Human; Organ Transplantation; Sarcoma, Kaposi, Human herpes virus 8, 616, Herpesvirus 8, Human, Screening, Herpesviridae Infections / epidemiology, Humans, Survey, Sarcoma, Kaposi

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
12
Top 10%
Average
Top 10%
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