AbstractApproach behavior, defined as differences in behavior to an incentive event and anger at its removal, was assessed during contingency learning in 87 5‐month olds was related to maternal ratings of mastery behaviors at 2 years. Mothers reported on infants' concurrent temperament, as well as the occurrence of anger and tantrums, and their own anger at 12 months. Approach behavior was expected to predict persistence with objects and persistent motor behavior, but not negative reactions to failure. Negative reactions to failure were expected to be mediated by a distress‐prone temperament. The moderating effect of maternal anger on these relations was also explored using conditional process regression models. Controlling for soothability, early approach behavior predicted toddlers' persistence, especially gross motor persistence, moderated by maternal anger. With more maternal anger, approach behavior and toddler's persistence were more strongly related. Distress to limits, infant anger at 12 months, and maternal anger were significantly correlated, but only infant anger was related to negative reactions to failure. Prior to 6 months, goal‐directed behavior is related to later behavioral persistence, but maternal responses to child anger are an important contributor to this relation and by 12 months, infant anger directly predicts mastery frustration at 2 years.