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Journal of the Royal Statistical Society Series C (Applied Statistics)
Article . 2018 . Peer-reviewed
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Article . 2018
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Article . 2018
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The Role of Secondary Outcomes in Multivariate Meta-Analysis

The role of secondary outcomes in multivariate meta-analysis
Authors: White, IR; Copas, JB; Jackson, D; Riley, RD;
APC: 1,694.53 EUR

The Role of Secondary Outcomes in Multivariate Meta-Analysis

Abstract

SummaryUnivariate meta-analysis concerns a single outcome of interest measured across a number of independent studies. However, many research studies will have also measured secondary outcomes. Multivariate meta-analysis allows us to take these secondary outcomes into account and can also include studies where the primary outcome is missing. We define the efficiency E as the variance of the overall estimate from a multivariate meta-analysis relative to the variance of the overall estimate from a univariate meta-analysis. The extra information gained from a multivariate meta-analysis of n studies is then similar to the extra information gained if a univariate meta-analysis of the primary effect had a further n(1−E)/E studies. The variance contribution of a study's secondary outcomes (its borrowing of strength) can be thought of as a contrast between the variance matrix of the outcomes in that study and the set of variance matrices of all the studies in the meta-analysis. In the bivariate case this is given a simple graphical interpretation as the borrowing-of-strength plot. We discuss how these findings can also be used in the context of random-effects meta-analysis. Our discussion is motivated by a published meta-analysis of 10 antihypertension clinical trials.

Country
United Kingdom
Keywords

Multivariate meta-analysis, multiple outcomes, Multiple outcomes., Borrowing of strength, multivariate meta-analysis, Original Articles, Applications of statistics, borrowing of strength, R1, RA

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
16
Top 10%
Average
Top 10%
Green
hybrid