Mesenchymal stem cells and transplant tolerance

descriptionPublicationkeyboard_double_arrow_right Article 16 Jun 2014 English Publisher:WileyJournal:Nephrology, volume 19, pages 369-374 (issn: 1320-5358, eissn: 1440-1797,

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Authors: Aruna V, Vanikar; Hargovind L, Trivedi; Ashutosh, Kumar; Saroj Chooramani, Gopal; Vivek B, Kute;

doi: 10.1111/nep.12258

pmid: 24698403

Mesenchymal stem cells and transplant tolerance

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Abstract

AbstractDifferent strategies are being tried to induce transplant tolerance in clinical settings; however, none of them are both safe and effective. Mesenchymal stem cells have been found to be potent immunomodulators and immunosuppressants. We discuss in this review different sources of mesenchymal stem cells and the potent role of adipose tissue‐derived mesenchymal stem cells in induction of transplant tolerance including when to use them and how to use them for achieving the Utopian dream of transplant tolerance.

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Keywords

Immunomodulation, Graft Survival, Humans, Mesenchymal Stem Cells, Transplantation Tolerance, Mesenchymal Stem Cell Transplantation, Immunosuppressive Agents

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