Review of cobalamin status and disorders of cobalamin metabolism in dogs
Copyright policy )Review of cobalamin status and disorders of cobalamin metabolism in dogs
Abstract Disorders of cobalamin (vitamin B12) metabolism are increasingly recognized in small animal medicine and have a variety of causes ranging from chronic gastrointestinal disease to hereditary defects in cobalamin metabolism. Measurement of serum cobalamin concentration, often in combination with serum folate concentration, is routinely performed as a diagnostic test in clinical practice. While the detection of hypocobalaminemia has therapeutic implications, interpretation of cobalamin status in dogs can be challenging. The aim of this review is to define hypocobalaminemia and cobalamin deficiency, normocobalaminemia, and hypercobalaminemia in dogs, describe known cobalamin deficiency states, breed predispositions in dogs, discuss the different biomarkers of importance for evaluating cobalamin status in dogs, and discuss the management of dogs with hypocobalaminemia.
- Leipzig University Germany
- EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH Switzerland
- University of Zurich Switzerland
- Martin University United States
- Massey University New Zealand
10253 Department of Small Animals, methylmalonic acid, 630 Agriculture, 3400 General Veterinary, Veterinary medicine, Vitamin B 12 Deficiency, cobalamin deficiency, homocysteine, vitamin B12, folate, hypercobalaminemia, cubam receptor, Vitamin B 12, Dogs, SF600-1100, Animals, hypocobalaminemia, 570 Life sciences; biology, SMALL ANIMAL, Dog Diseases, Biomarkers
10253 Department of Small Animals, methylmalonic acid, 630 Agriculture, 3400 General Veterinary, Veterinary medicine, Vitamin B 12 Deficiency, cobalamin deficiency, homocysteine, vitamin B12, folate, hypercobalaminemia, cubam receptor, Vitamin B 12, Dogs, SF600-1100, Animals, hypocobalaminemia, 570 Life sciences; biology, SMALL ANIMAL, Dog Diseases, Biomarkers
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