Background Information pertaining to clinical presentation and outcome of neonatal New World camelids ( NWC ) is limited when compared to calves and foals. Hypothesis Values of variables at admission and subsequent treatment would predict survival in sick neonatal NWC . Animals Fifty‐six client‐owned sick neonatal NWC presented over a 10‐year period to the Purdue University Veterinary Teaching Hospital. Methods A retrospective study was performed. Inclusion criteria were NWC less than 30 days of age with complete medical records that presented between 2000 and 2010. Results The median age at presentation was 1 day (range 1–20). The most common diagnoses were systemic inflammatory response syndrome (50%), congenital defects (41%), ophthalmic lesions (21%), sepsis (16%), and gastrointestinal diseases (16%). Sixty‐six percent of NWC survived to discharge. Clinicopathologic findings on admission were variable and not specific for disorders. Factors associated with survival were absence of choanal atresia ( P  =   .001, OR : 55.9 [2.5–1,232]), administration of llama plasma ( P  =   .013, OR : 4.9 [1.4–17.7]), and antimicrobial treatment with trimethoprim‐sulfamethoxazole ( TMS ) ( P  =   .016, OR : 6.5 [1.3–32.2]). Conclusions and Clinical Importance The use of antibiotics, particularly TMS , and llama plasma are recommended in sick neonatal NWC . Results from this study could contribute toward defining a NWC ‐specific sepsis scoring system.