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GPVI and integrin αIIbβ3 signaling in platelets

descriptionPublicationkeyboard_double_arrow_right Article 01 Aug 2005 English Publisher:Elsevier BVJournal:Journal of Thrombosis and Haemostasis, volume 3, pages 1,752-1,762 (issn: 1538-7836,

Authors: Steve P. Watson; Andrew C. Pearce; Jocelyn M. Auger; Owen J. T. McCarty;

doi: 10.1111/j.1538-7836.2005.01429.x

pmid: 16102042

GPVI and integrin αIIbβ3 signaling in platelets

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Abstract

This review summarizes recent developments in our understanding of the molecular basis of platelet activation by two distinct types of surface receptor, the immunoglobulin GPVI, and the integrin alphaIIb beta3 (also known as GPIIbIIIa). These two classes of receptor signal through similar yet distinct tyrosine kinase-based signaling cascades leading to activation of phospholipase C gamma2. The significance of these signaling cascades in platelet adhesion and platelet aggregation at arterial rates of shear is discussed.

Related Organizations

University of Birmingham
United Kingdom

Keywords

Enzyme Precursors, Platelet Aggregation, Molecular Sequence Data, Intracellular Signaling Peptides and Proteins, Platelet Glycoprotein GPIIb-IIIa Complex, Platelet Membrane Glycoproteins, Protein-Tyrosine Kinases, Platelet Activation, Models, Biological, Enzyme Activation, Platelet Adhesiveness, src-Family Kinases, Animals, Humans, Syk Kinase, Amino Acid Sequence, Collagen, Signal Transduction

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