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image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Alcoholism Clinical ...arrow_drop_down
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Alcoholism Clinical and Experimental Research
Article . 1984 . Peer-reviewed
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Correlative Analysis of Ethanol‐Related Phenotypes in Rat Inbred Strains

Authors: Richard A. Deitrich; Karen P. Spuhler;

Correlative Analysis of Ethanol‐Related Phenotypes in Rat Inbred Strains

Abstract

As a summary presentation of the ethanol‐related traits in the rat inbred strains, the responses to ethanol for various traits of the eight strains were analyzed. The intercorrelations among the means of the strains were computed and the interrelationships among the strain con‐elations were determined further by partial correlation and factor analysis. Sources of data on strain ethanol response included measures from laboratories of Drs. Deitrich, Li, Erickson, Pohorecky, and Tabakoff, who have participated in this joint study on the development of the rat heterogeneous stock (N/Nih). Although there are problems with estimating strain correlations from data collected in different laboratories, some informative associations among the ethanol‐related traits were apparent Genetic variation for behavioral and physiological responses to ethanol was indicated by the inbred strain distribution. The strains cleariy differed in response to ethanol, with the mean of the National Institutes of Health stock falling intermediate within the range of the inbred strain distribution. For the ethanol‐related traits considered jointly, an association between initial behavioral sensitivity, ethanol intake, and metabolism, as well as an association between development of tolerance, initial sensitivity, and several physiological measures, was suggested. Thus, the rat heterogeneous stock, a systematically outbred population, should provide a useful animal model with which to study the physiological oasis for ethanol intake and preference, response to acute ethanol, and the development of tolerance.

Keywords

Alcohol Drinking, Ethanol, Metabolic Clearance Rate, Rats, Inbred Strains, Drug Tolerance, Rats, Alcoholism, Disease Models, Animal, Phenotype, Reflex, Animals, Humans, Sleep Stages, Corticosterone

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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
76
Top 10%
Top 10%
Top 10%
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