Regulation of CHK1 by the Ubiquitin–Proteasome System

descriptionPublicationkeyboard_double_arrow_right Article 06 Jan 2020 France English Publisher:WileyJournal:The FEBS Journal, volume 287, pages 1,982-1,984 (issn: 1742-464X, eissn: 1742-4658,

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Authors: Cartel, Maëlle; Didier, Christine;

doi: 10.1111/febs.15173

pmid: 31904911

Regulation of CHK1 by the Ubiquitin–Proteasome System

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Abstract

The checkpoint kinase 1 (CHK1) is a master regulator of genome integrity in vertebrate cells. Despite its important cell cycle functions, its regulation is still incompletely understood. Cassidy et al. provide novel insights on the regulation of the CHK1 abundance by the HECT E3 ligase HUWE1 during unperturbed cell cycle as well as in response to replicative stress. These results may help us to apprehend the underlying mechanism of tumorigenesis.

Country

France

Related Organizations

Inserm
France
Cancer Research Center of Toulouse
France
Paul Sabatier University
France
University of Toulouse
France
Université de Toulouse
France

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Keywords

Proteasome Endopeptidase Complex, proteasome system, Protein Stability, Ubiquitin, CHK1, Ubiquitin-Protein Ligases, [SDV] Life Sciences [q-bio], Proteasome Endopeptidase Complex* / metabolism, Ubiquitin*, Ubiquitin-Protein Ligases / metabolism, ubiquitin, Checkpoint Kinase 1, Ubiquitin-Protein Ligases / genetics, Checkpoint Kinase 1 / genetics

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