Abstract Neutrophil extracellular traps ( NET s), large chromatin structures casted with various proteins, are externalized by neutrophils upon induction by both self‐ and non‐self‐stimuli. It has become clear that NET s are potent triggers of inflammation in autoimmune skin diseases. Moreover, the ability of NET s to trap pathogens suggests a crucial role in innate host defense. However, the outcome of the encounter between pathogens and NET s remains highly controversial. Here, we discuss recent insights into the morphology and formation of NET s, their role in skin inflammation and how NET s might contribute to host protection in skin infection.