Insulin‐like growth factor‐1: roles in androgenetic alopecia
Copyright policy )Insulin‐like growth factor‐1: roles in androgenetic alopecia
AbstractOf all the cytokines or growth factors that have been postulated to play a role in hair follicle, insulin‐like growth factor‐1 (IGF‐1) is known to be regulated by androgens. However, how IGF‐1 is altered in the balding scalp has not yet been investigated. In this study, expressions of IGF‐1 and its binding proteins by dermal papilla (DP) cells obtained from balding versus non‐balding hair follicles were quantified using growth factor array. DP cells from balding scalp follicles were found to secrete significantly less IGF‐1, IGFBP‐2 and IGFBP‐4 (P < 0.05) than their non‐balding counterparts. Our data confirmed that the downregulation of IGF‐1 may be one of the important mechanisms contributing to male pattern baldness.
- Chulalongkorn University Thailand
Adult, Male, Scalp, Alopecia, Middle Aged, Insulin-Like Growth Factor Binding Protein 1, Insulin-Like Growth Factor Binding Proteins, Insulin-Like Growth Factor Binding Protein 2, Insulin-Like Growth Factor Binding Protein 3, Insulin-Like Growth Factor Binding Protein 4, Humans, Insulin-Like Growth Factor I, Hair Follicle, Insulin-Like Growth Factor Binding Protein 6, Cells, Cultured
Adult, Male, Scalp, Alopecia, Middle Aged, Insulin-Like Growth Factor Binding Protein 1, Insulin-Like Growth Factor Binding Proteins, Insulin-Like Growth Factor Binding Protein 2, Insulin-Like Growth Factor Binding Protein 3, Insulin-Like Growth Factor Binding Protein 4, Humans, Insulin-Like Growth Factor I, Hair Follicle, Insulin-Like Growth Factor Binding Protein 6, Cells, Cultured
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