Cytokines of the IL‐17 family in psoriasis

descriptionPublicationkeyboard_double_arrow_right Article 24 May 2020 Germany, Switzerland, Germany English Publisher:WileyJournal:JDDG: Journal der Deutschen Dermatologischen Gesellschaft, volume 18, pages 675-681 (issn: 1610-0379, eissn: 1610-0387,

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Authors: Lauffer, Felix; Eyerich, Kilian; Boehncke, Wolf‐Henning; Asadullah, Khusru; Beissert, Stefan; Ghoreschi, Kamran; Schön, Michael P.;

doi: 10.1111/ddg.14124

pmid: 32447845

Cytokines of the IL‐17 family in psoriasis

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Abstract

SummaryVarious immune cells and their messenger substances influence the development of psoriasis. Cytokines of the IL‐17 family are of particular importance. In addition to IL‐17A, which plays a central role in the pathogenesis of psoriasis, other subtypes of the IL‐17 family also have a proinflammatory effect. This review provides an up‐to‐date overview of the immunopathogenesis of psoriasis with regard to the six IL‐17 subtypes, in particular their physiological and pathogenic properties, as well as their significance for psoriasis therapy.

Countries

Germany, Switzerland, Germany

Related Organizations

University of Geneva
Switzerland
Charité - University Medicine Berlin
Germany
University Hospital of Geneva
Switzerland
TU Dresden
Germany
Technical University of Munich
Germany

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Keywords

Interleukin-17/physiology, Receptors, Interleukin-17, Humanized/therapeutic use, Interleukin-17, Psoriasis/drug therapy/immunology, 616.07, Antibodies, Monoclonal, Humanized, Antibodies, 616, Monoclonal, Receptors, Humans, Psoriasis, Interleukin-17/chemistry/physiology

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