AbstractOne of the great challenges in word learning is that words are typically uttered in a context with many potential referents. Children's tendency to associate novel words with novel referents, which is taken to reflect a mutual exclusivity (ME) bias, forms a useful disambiguation mechanism. We study semantic learning in pragmatic agents—combining the Rational Speech Act model with gradient‐based learning—and explore the conditions under which such agents show an ME bias. This approach provides a framework for investigating a pragmatic account of the ME bias in humans but also for building artificial agents that display an ME bias. A series of analyses demonstrates striking parallels between our model and human word learning regarding several aspects relevant to the ME bias phenomenon: online inference, long‐term learning, and developmental effects. By testing different implementations, we find that two components, pragmatic online inference and incremental collection of evidence for one‐to‐one correspondences between words and referents, play an important role in modeling the developmental trajectory of the ME bias. Finally, we outline an extension of our model to a deep neural network architecture that can process more naturalistic visual and linguistic input. Until now, in contrast to children, deep neural networks have needed indirect access to (supposed to be novel) test inputs during training to display an ME bias. Our model is the first one to do so without using this manipulation.