Methylisothiazolinone: second ‘epidemic’ of isothiazolinone sensitization

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 14 Mar 2014 Portugal English Publisher:WileyJournal:Contact Dermatitis, volume 70, pages 242-243 (issn: 0105-1873, eissn: 1600-0536,

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Authors: Gameiro, A; Coutinho, I; Ramos, L; Gonçalo, Margarida;

doi: 10.1111/cod.12200

pmid: 24628348

handle: 10400.4/1683 , http://hdl.handle.net/10400.4/1683

Methylisothiazolinone: second ‘epidemic’ of isothiazolinone sensitization

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Abstract

Isothiazolinones are used as biocides in a wide variety of products, such as cosmetics, detergents, and industrial products. In the 1980s, a formulation with methylchloroisothiazolinone (MCI) and methylisothiazolinone (MI) was responsible for an allergic contact dermatitis ‘epidemic’. To control this phenomenon, a maximum allowed dose was set. However in 2005, MI alone was introduced in cosmetics, and this was followed by a new ‘epidemic’ of sensitization to MI and MCI/MI (1). We performed a retrospective study, consulting the medical files of patch tested patients reactive to ISs, from 2005 to 2013. MCI/MI was tested at 100 ppm in water (TROLAB® patch test allergens, Almirall Hermal

Country

Portugal

Related Organizations

University of Coimbra
Portugal
Centro Hospital e Universitário de Coimbra
Portugal
Hospitais da Universidade de Coimbra
Portugal

Keywords

Adult, Male, Adolescent, Dermatite Ocupacional, Cosmetics, Middle Aged, Patch Tests, Cohort Studies, Europe, Thiazoles, Young Adult, Dermatitis, Occupational, Child, Preschool, Dermatitis, Allergic Contact, Humans, Dermatite de Contacto Alérgica, Female, Child, Epidemics, Aged, Disinfectants, Retrospective Studies

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