Bacterial injection machines: Evolutionary diverse but functionally convergent

descriptionPublicationkeyboard_double_arrow_right Article 16 Jan 2020 Spain English Publisher:WileyJournal:Cellular Microbiology, volume 22 (issn: 1462-5814, eissn: 1462-5822,

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Authors: Sophie Bleves; Jorge E. Galán; Matxalen Llosa;

doi: 10.1111/cmi.13157

pmid: 31891220

pmc: PMC7138736

handle: 10261/241469 , 10902/34719

Bacterial injection machines: Evolutionary diverse but functionally convergent

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Abstract

Many human pathogens use Type III, Type IV, and Type VI secretion systems to deliver effectors into their target cells. The contribution of these secretion systems to microbial virulence was the main focus of a workshop organised by the International University of Andalusia in Spain. The meeting addressed structure-function, substrate recruitment, and translocation processes, which differ widely on the different secretion machineries, as well as the nature of the translocated effectors and their roles in subverting the host cell. An excellent panel of worldwide speakers presented the state of the art of the field, highlighting the involvement of bacterial secretion in human disease and discussing mechanistic aspects of bacterial pathogenicity, which can provide the bases for the development of novel antivirulence strategies.

Country

Spain

Related Organizations

Aix-Marseille University
France
French National Centre for Scientific Research
France
Inserm
France
Laboratoire d'Ingénierie des Systèmes Macromoléculaires
France
University of Cantabria
Spain

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Keywords

Effector protein, bacterial secretion, [SDV.BC.IC] Life Sciences [q-bio]/Cellular Biology/Cell Behavior [q-bio.CB], [SDV.BBM.BM] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology, Type IV Secretion Systems, Bacterial secretion, Bacterial Proteins, Type III Secretion Systems, pathogenicity, Machinery assembly, Pathogenicity, Humans, toxin, Bacterial Secretion Systems, effector protein, Microbial virulence, Type VI Secretion System, Protein translocation, protein translocation, Bacteria, Virulence, Host subversion, Type IV Secretion System, Type VI Secretion Systems, Type III Secretion System, Antibacterial, antibacterial, Type III secretion system, Protein Transport, microbial virulence, Type IV secretion system, Spain, machinery assembly, Type VI secretion system, [SDV.MP.BAC] Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology, Toxin, host subversion

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