The Role of Pyruvate Kinase M2 in Cancer Metabolism

descriptionPublicationkeyboard_double_arrow_right Article 01 Nov 2015 English Publisher:WileyJournal:Brain Pathology, volume 25, pages 781-783 (issn: 1015-6305, eissn: 1750-3639,

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Authors: Vivian M. Liu; Matthew G. Vander Heiden;

doi: 10.1111/bpa.12311

pmid: 26526946

pmc: PMC8029046

The Role of Pyruvate Kinase M2 in Cancer Metabolism

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Abstract

AbstractThe M2 isoform of pyruvate kinase is expressed preferentially in cancer cells over other pyruvate kinase isoforms. PKM2 is unique in its ability to be regulated allosterically by nutrients and growth signaling pathways, allowing cells to adapt their metabolic program to match physiological needs in different environments. Here, we discuss the role of pyruvate kinase M2 in glioma and in cancer metabolism.

Related Organizations

Dana-Farber Cancer Institute
United States
Harvard University
United States
Massachusetts Institute of Technology
United States

Keywords

Brain Neoplasms, Pyruvate Kinase, Animals, Humans, Glioma

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