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Biometrics
Article . 2022 . Peer-reviewed
License: Wiley Online Library User Agreement
Data sources: Crossref
Biometrics
Article . 2023
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Instrumental Variable Estimation of the Causal Hazard Ratio

Authors: Linbo Wang; Eric Tchetgen Tchetgen; Torben Martinussen; Stijn Vansteelandt;

Instrumental Variable Estimation of the Causal Hazard Ratio

Abstract

AbstractCox's proportional hazards model is one of the most popular statistical models to evaluate associations of exposure with a censored failure time outcome. When confounding factors are not fully observed, the exposure hazard ratio estimated using a Cox model is subject to unmeasured confounding bias. To address this, we propose a novel approach for the identification and estimation of the causal hazard ratio in the presence of unmeasured confounding factors. Our approach is based on a binary instrumental variable, and an additional no-interaction assumption in a first-stage regression of the treatment on the IV and unmeasured confounders. We propose, to the best of our knowledge, the first consistent estimator of the (population) causal hazard ratio within an instrumental variable framework. A version of our estimator admits a closed-form representation. We derive the asymptotic distribution of our estimator and provide a consistent estimator for its asymptotic variance. Our approach is illustrated via simulation studies and a data application.

Country
Denmark
Keywords

Causality, Models, Statistical, Bias, Computer Simulation, Proportional Hazards Models

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    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    13
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    Top 10%
    influence
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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
13
Top 10%
Average
Top 10%
Green
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